The risk of COVID-19 infection gradually increased after the second vaccine dose in the study
 |
Results confirm that protection wanes with time and suggest
a third ( supporter) cure might be warranted |
A study published by BMJ plant that 90 days after entering
the alternate cure of Pfizer’s BioNTech vaccine, the threat of constricting
covid-19 gradationally increases.
The research was conducted by the Leumit Institute of Health
Services in Israel. Israel was one of the first countries to launch a
large-scale covid-19 vaccination campaign in December 2020, but since June
2021, the campaign has been infected again.
The results of the study confirmed that the Pfizer-BioNTech
vaccine provided excellent protection in the first few weeks after vaccination,
but showed that the protective effect for some people diminished over time.
Worldwide,
large-scale covid-19 vaccination campaigns are
helping to control the spread of the virus, but even in countries with high
vaccination rates, breakthrough infections may occur. Scientists believe this
is due to immunity over time Gradually lost.
To this end, the researchers checked the electronic health
records of 80,057 adults (average age 44) who underwent PCR testing at least
three weeks after the second injection and had no evidence of previous covid-19
infection.
Of these 80,057 participants, 7,973 (9.6%) tested positive. These individuals were then matched with negative controls of the same age and race who were tested in the same week.
Since the second administration, the rate of positive
results has increased over time. For example, in all age groups, 1.3% of
participants tested positive 21-89 days after the second dose, but increased to
2.4% after 90-119 days; 4.6% after 120-149 days; and 150-179 days later 10.3%;
15.5% after 180 days or more.
Compared with the first 90 days after the alternate cure,
the threat of infection in all age groups is2.37 times advanced after 90-119
days;2.66 times advanced after 120-149 days;2.82 times advanced after 150-179
days; 180 days Or2.82 times advanced after a longer period of time.
The researchers admit that the interpretation of their
findings is limited by the design of the observations, and they cannot rule out
the possibility that other unmeasured factors, such as family size, population
density, or virus strains, may have an impact.
However, this is a large study of all people who received
the same vaccine, and the researchers were able to analyze the data in detail
and show that the results are reliable.
Therefore, they concluded that in individuals who received
two doses of the Pfizer-BioNTech vaccine, protection appeared to decrease over
time, and the risk of breakthrough infection gradually increased compared to
the protection provided during the first 90 days.
They added that the results suggest that a third dose of
vaccine may need to be considered.
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